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doi:10.3390/molecules28031447 Forman HJ, Zhang H, Rinna A

doi: 10.1016/j.immuni.2011.07.010 107 MaXJTianDYXuDYangDFZhuHFLiangZHet al

Bottom Line: BPC-157 is a master modulator of the healing process, but it isnt a replacement for proper rehab, nutrition, and sleep

This is a critical methodological confounder that has been inflating the perceived muscle wasting signal in large clinical trials

Conflicting results were observed from ERK5 kinase inhibitors, ERK5 PROTAC, and its genetic downregulation and depletion, and paradoxical activation of the transcriptional activity of ERK5 mediated by kinase inhibitors may contribute to these ambiguous results