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Enrollment and Patient Population TRIUMPH-1 enrolled approximately 2,300 patients, making it one of the largest obesity drug trials in recent history
If b12 deficiency exists and causes fatigue that limits physical activity, correcting the deficiency may indirectly support weight loss by enabling more movement
NICE guidance (TA875) supports the use of semaglutide for weight management in specific circumstances through specialist weight management services, but combination pharmacotherapy requires careful justification
Early-cycle water retention typically subsides within 2 to 4 weeks
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