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Dried peptides were resuspended in 0.1% TFA and Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) performed in single replicate injections as previously described 93 using an Ultimate 3000 nano-HPLC coupled to a Q-Exactive mass spectrometer (Thermo Scientific) via an EASY-Spray source
and ways to modulate downstream phosphodiesterases and soluble guanylyl cyclases
Plant GPXs are similar to animal GPXs, but their active region contains cysteine instead of selenocysteine
Beyond their reactivity in stroke, astrocytes also exhibit a form of autophagy plasticity, dynamically adjusting autophagic activity in response to pathological stimuli such as A accumulation
These findings support further evaluation in the ongoing phase 3 programme
