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Besides people who have an absorption problem, some individuals prefer a plant-based diet and thus cant access B12 from food
Getting the right type of B12 can be the difference between experiencing many benefits and feeling no difference at all
not present in plants Daily requirement: ~ 23 g/day Body stores: 25 mg , mostly in the liver (sufficient for 25 years) Absorption Pathway : In the mouth/stomach: B12 is protein-bound in food Stomach acid and pepsin release B12 from food proteins B12 binds to haptocorrin (also called R-binder or transcobalamin I) secreted by salivary glands and gastric mucosa In the small intestine : In the duodenum , pancreatic proteases degrade haptocorrin Free B12 then binds to intrinsic factor (IF) , a glycoprotein secreted by gastric parietal cells The B12IF complex travels to the terminal ileum , where it binds to cubilin receptors and is absorbed via receptor-mediated endocytosis 1 In the enterocyte and bloodstream: Inside enterocytes, B12 dissociates from IF It binds to transcobalamin II (TCII) for systemic transport Only B12TCII complex (called holotranscobalamin ) is biologically active and taken up by tissues Storage and transport: B12 is stored in the liver (main site), but also in muscle Transcobalamin II transports active B12 to tissues
SUPPORTS ENERGY PRODUCTION RED BLOOD CELL FORMATION AIDS IN GUT HEALTH IMPROVEMENTS PROMOTES NEUROLOGICAL FUNCTIONS BOOST METABOLISM PROMOTE OVERALL HEALTH POTENTIAL TO HELPS THOSE WITH MTHFR The Methylcobalamin B12 formula is administered as an Intramuscular injection in the upper arm, buttock or upper thigh
PubMed: 21184799 Growth Hormone Fragment Peptide-Induced Lipolysis: Comparison of AOD 9604, HGH, and Thiazolidinediones in vitro Liu X, Ng FM, Shen Y, et al
