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Because microsomes are only a part of the subcellular structure, they lack the synergistic effect of other key enzymes (such as NAT and ST) and coenzymes in the whole cell, so some metabolic reactions that require the participation of phase II enzymes cannot be carried out in this system
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The specific dosages studied in many of these animal models are very high when extrapolated to human equivalent doses
Pircher A, Treps L, Bodrug N, Carmeliet P
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