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These shifts can manifest as pain, nausea or, in rare cases, gallbladder infections
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Therefore, in the past GIP has been considered an unappealing therapeutic target for T2DM
One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)
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