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The reason why testosterone is neuroprotective is simply because it aromatizes at a rate that provides a sufficient amount of estradiol to balance out the androgenicity in the body

That being said, microdoses do have key differences from standard doses

The liver detoxifies harmful substances by a complex series of chemical reactions

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similarly, moderate lipid peroxidation has certain positive effects Since, lipid peroxidation is a double-edged sword it is essential the beneficial and toxic effects be well balanced [92] The effective therapeutic interventions should therefore balance between the oxidation and antioxidant effects of lipid peroxides