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The reaction was terminated by the addition of 400 L phase A (0.1% trifluoracetic acid) before being fractionated into 1 mL volume by reverse-phase high-performance liquid chromatography (RP-HPLC, Waters 600 SimiPrep system) on a C18 column

Examination assesses sensation, thumb and grip strength, finger movement, wrist mobility and areas of tenderness, and looks for thumb muscle wasting

In this review, we will present different molecules designed to selectively eliminate senescent cells and which are based on new identified targets overexpressed in different senescent models

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