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Superposition of the third trajectory middle stage with the previous active GLP-1R structure (PDB: 5VAI) revealed the apo-state GLP-1R may adopt a similar extended ECD conformation as in the GLP-1-bound structure (Supplementary Fig

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If retatrutide is licensed by the MHRA in the future, Second Nature plans to assess it as an option alongside our existing Wegovy and Mounjaro programmes

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E., Usuelli, V., Pastore, I., Lazzaroni, E., Assi, E., Seelam, A

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