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Thats why the drugs are typically started at a low dose and increased over several months, Kothari says
Mechanism of Action: Why Two Receptors May Matter More Tirzepatide targets both GLP-1 and glucose-dependent insulinotropic polypeptide (GIPR) receptors
Nevertheless, a small, randomized trial evaluating vildagliptin in patients with diabetes and HF with reduced ejection fraction, showed no increase in HF-related hospitalizations, but a harmful enlargement of left ventricular volumes of unknown cause with this drug (McMurray et al., 2018)
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