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Their evaluation of the effect of GLP-1 was also aided by their access to RIAs for GLP-1 (Holst 2024)

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Metabolic Health In addition to weight loss, Calibrate results show improvements in some metabolic health markers

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PMC 3283181

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The FDA review of adverse events reports found significant weight gain and edema cases, which are heart failure warning signs

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However, it has also been reported that although deletion of hepatocyte Dpp4 expression abolished the obesity-induced rise in circulating DPP-4 and was associated with reduced levels of proinflammatory cytokines in hepatocytes and adipose tissue, levels of circulating soluble DPP-4 per se did not correlate with tissue or systemic inflammation (82)

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