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A Phase 2 trial (NCT01311518) was designed to test RGN-352 in ~75 heart attack patients, but was placed on FDA clinical hold in 2011 due to manufacturing (GMP) compliance issues at the contract site not safety concerns with the drug itself
Furthermore, health risks, family history, other medications, age, and personal health factors, are also going to dictate the results you are going to see, and how quickly you can expect to see those results
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This complementarity forms the basis of the narrative logic of the Wolverine stack, but it does not replace peer-reviewed validation, which does not yet exist
Of course, it is unwise to directly compare the doses given to animals and the doses given to humans, as the bodys surface area should also be taken into account when translating doses between species
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