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Researchers discerned no correlation between the incidence of muscle cramps and factors such as edema, ascites, diuretic use, alcohol consumption, but have identified the presence of liver cirrhosis, higher total serum bilirubin levels, and lower serum albumin levels as risk factors for development of muscle cramps (25, 28)

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The low redox potential of glutathione (E = -240 mV), combined with its high intracellular concentration (110 mM), contribute to its large redox buffering capacity [20,21]