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Notably, administering PQQ has shown beneficial effects in attenuating clinically relevant dysfunctions, such as mitochondrial dysfunction, inflammation, hyperlipidemia, and lipotoxicity
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All experiments were conducted with adherence to the National Institutes of Health Guide for the Care and Use of Laboratory Animals
While studies attempting to localize the pathology in FMS to peripheral tissues have failed in showing any abnormalities in muscle tissue, Staud and coworkers did show that enhanced central pain processing can occur via continued peripheral muscle afferent input, Their study demonstrated that muscle lidocaine injections increased local pain thresholds and decreased remote secondary heat hyperalgesia in fibromyalgia patients, emphasizing the important role of peripheral impulse input in maintaining central sensitization
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