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These medications should also be used cautiously in individuals with certain medical conditions, such as epilepsy, untreated hypothyroidism, obesity, hyperglycemia, or elevated levels of plasma fatty acids, as these conditions may increase the risk of adverse effects or alter the drugs response

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Repeatedly injecting into the same spot can lead to lipohypertrophy (lumpy areas of fat buildup) or lipoatrophy (loss of fatty tissue), both of which can impair medication absorption and affect glycaemic control

In experimental models, it is used to investigate melanocortin mediated CNS pathways and downstream signaling, with a mechanistic focus distinct from direct peripheral vasodilatory (blood flow) mechanisms