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Allergic Reaction Lip products, toothpaste, or skincare ingredients may cause irritation that leads to a dark black spot on lip

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Curcumin can activate Nrf2 signaling pathway via inhibiting Keap1, upregulating Nrf2 and inducing the nuclear translocation of Nrf2 ( via Sirtuin-1-Nrf2-ARE signaling pathway (Liu et al., 2022c)