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Glutathione primarily works as an antioxidant in the body and belongs to the group of dietary supplements
This could be related to stronger appetite suppression at higher doses leading to greater calorie and nutrient deficits, more pronounced GI side effects causing worse dehydration, or a more significant pharmacological effect at higher doses
The honest answer is that you feel some effects within days, but the full picture takes months
Wilkins et al., 2012), mainly in kidney and liver, and tricarboxylate carrier (TTC, SLC25A1) in brain mitochondria and astrocytes (Wadey et al., 2009)
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