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The starting dose of semaglutide is 0.25 mg once a week (subcutaneously) for the first 4 weeks

Given the progressive nature of the disorder, disease pathogenesis is mainly triggered by continual processes such as geometric accumulation of oxidative radicals brought about by cellular inclusions and mitochondrial dysfunction 8,9,10

These legitimate concerns deserve honest discussion without catastrophizing or minimizing

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Microneedling radiofrequency, where small needles are used to create controlled skin injury leading to an increase in collagen and elastin, has also been tried