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The authors noted that, within the context of their focus on the chloroplast, NADPH could be produced from the photosynthetic electron transport chain (thus providing an additional sink for electrons) or, in the dark, by the dehydrogenases of the oxidative pentose phosphate pathway (Foyer and Halliwell 1976)

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Tosoh, Tokyo Japan) and electrospray ionization time-of-flight mass spectrometry with a Hitachi Nano Frontier liquid chromatographymass spectrometry (LC-MS) system (Tokyo, Japan)

So, when your B12 levels are low, its no surprise your body feels like its running on empty