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The hypogonadism is of hypothalamic origin, and generally there is hypogonadotropism with decreased testosterone or estrogen and decreased FSH and LH in both sexes
PBA and TUDCA were furthermore shown to prevent ER stress-induced inhibition of apoB100 secretion, a feature contributing to hepatic steatosis (138) and to ameliorate atherosclerosis in mouse models (139)
30,31 Moreover, lipid metabolism in immune cells is closely linked to immune regulation in metabolic diseases, such as diabetes, obesity, and autoimmune diseases such as rheumatoid arthritis (RA)
The literature regarding HS is limited, but a case report has shown improvement in HS after the initiation of liraglutide which is postulated to be because of decreased IL-17 and TNF- which are known to play a role in the pathogenesis of HS
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