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Areas with thicker skin, like the backs of hands, elbows, and knees, can potentially tolerate higher concentrations

It may also interfere with the PI3K/Akt/mTOR signaling pathways involved in HIF-1 activation and promote the degradation of HIF-1 protein through the 26S proteasome system, a cellular machinery responsible for protein breakdown 48

1 2 3 "Anemia Screening", StatPearls , Treasure Island (FL): StatPearls Publishing, PMID 29763080, retrieved March 30, 2026 "Reticulocyte Count: Testing, Purpose & Results"

N Engl J Med 2015;373:224757.ArticlePubMed 67

I do my stretches, stay active, and run a maintenance protocol every few months