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Long-term data is still evolving for both formulations

If you just wanted to lose five or ten pounds, this is not the medication for you, Simonetti advises

In KARDIA-3 (presented at ESC 2025), a 300 mg dose reduced office SBP by 5.0 mmHg (p = 0.0431, with clinical significance noted despite multiple testing adjustments), alongside improvements in 24-h and nighttime control, and serious adverse events of 3.8% versus 4.5% with placebo [89]

Their fecal specimens were transported to the specimen bank of Union Hospital within 24 h for long-term storage at 80

Ozempics predecessor, Saxenda, caused similar side effects and was approved in 2014