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Figure 1 The TME of osteosarcoma is characterized by a dense, mineralized extracellular matrix (ECM) and the infiltration of immunosuppressive cell populations that collectively orchestrate resistance to immunotherapy
Author contributions RR: Formal Analysis, Validation, Data curation, Methodology, Conceptualization, Writing review & editing, Writing original draft, Investigation
A 2018 paper published in Current Pharmaceutical Design reported that BPC-157 interacted with the NO system to modulate blood pressure in rats, producing both hypertensive and hypotensive responses depending on the model [8]
As a precautionary measure, the medication is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
