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The SELECT trial with semaglutide 2.4 mg demonstrated a 20% reduction in MACE among patients with established cardiovascular disease and overweight or obesity, even in those without diabetes
Many individuals prescribed these medications may have pre-existing risk factors for reflux, including obesity itself, which is a well-established independent risk factor for GORD
Removing those foods reduces the immune burden and allows the gut to heal
The only therapeutic approach currently in clinical trials is AAV2-BDNF gene therapy, which requires neurosurgical implantation
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