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This dual action activates regenerative TGF- signaling while blocking fibrotic TGF-1/Smad2/3 pathways, demonstrating context-dependent regulatory sophistication
Bull Exp Biol Med 167(5):641644 Ku BM, Lee YK, Jeong JY, Mun J, Han JY, Roh GS, Kim HJ, Cho GJ, Choi WS, Yi G-s (2007) Ethanol-induced oxidative stress is mediated by p38 MAPK pathway in mouse hippocampal cells
Studies have also revealed that extravasation of lymphoid cells mediated by the vascular and intracellular adhesion molecules VCAM-1 and ICAM-1 is a seminal event in the pathophysiology of multiple sclerosis
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