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Specifically, mitochondrial TBC1D15 promotes the hydrolysis of Rab7 GTP at the MLCS, leading to untethering of these contacts (Wong et al., 2018) and subsequent release of Rab7 effector proteins from GTP-bound Rab7 and lysosomal membranes, thereby influencing lysosomal dynamics
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Testosterone replacement therapy is a medical treatment designed to restore testosterone levels in men with clinically low T, defined by the American Urological Association as total testosterone below 300 ng/dL on two separate morning blood draws
Upregulation of GSTT1 and GSTP1 might have important consequences for TCC growth by providing a reduced cellular environment and inhibition of apoptotic pathways
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