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For UK researchers unable to source verified pre-filled pens, the next-best alternative is pharmaceutical-grade lyophilized powder reconstituted immediately before use

For women of childbearing potential, effective contraception is recommended during treatment with semaglutide and for at least 2 months after discontinuation

Long-term use of cortisone injections can cause various side effects, including tissue atrophy, weakened tendons, and blood sugar elevation

Guirguis says any new therapy needs to be cost effective, safe, efficacious, have good bioavailability, have a simple dosing regimen and get patients acceptability and affordability