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A small subset of "sentinel" participants is dosed first, before the rest of the cohort, as an additional safeguard
Behav Brain Res 366:96107
The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: a double blind, randomized, placebo-controlled study
Most patients see results within 4 to 8 weeks
Malla, R
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