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M.MachineniS.et al (2023)

The researchers propose that DSIPs observed effects, particularly the selective increase in V3 and ADP/t without affecting VDNP, suggest that it does not stimulate the activity of respiratory chain enzymes or substrate transporters, as these would typically affect VDNP

At a structural level, research highlighted several features linked to methylene blue that may give it an advantage: Small molecular weight with both hydrophilic and lipophilic properties, which may help it move through different tissues once absorbed

J Clin Endocrinol Metab 88:46964701 Santoprete A, Capito E, Carrington PE et al (2011) DPP-IV-resistant, long-acting oxyntomodulin derivatives

GLP-1 RA treatment has been reported to increase irisin levels in patients with obesity and T2D