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Because TB-500 reaches all tissues rather than concentrating at one site, the dosing strategy focuses on sustaining a systemic therapeutic level across the cycle rather than targeting a precise anatomical location
For Lebers optic atrophy or smokers blindness, the usual dose starts at 1000mcg, given daily for 2 weeks, followed by twice weekly
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Am J Physiol Renal Physiol 295(5):F1365F1375
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