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The most commonly reported side effects of GLP-1 receptor agonists, documented across multiple large randomized controlled clinical trials enrolling thousands of participants, are gastrointestinal: nausea, vomiting, diarrhea, constipation, and abdominal discomfort, all of which are most commonly reported during the initial titration phase when dosage is being escalated from a low starting point toward a therapeutic target and the body is still adapting to the mechanism of action