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Kim J, Chu J, Shen X, Wang J, Orkin SH (2008)
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reduces wrinkles 55%
Cold elicits the simultaneous induction of fatty acid synthesis and -oxidation in murine brown adipose tissue: prediction from differential gene expression and confirmation in vivo
However, this approach is not routine first-line treatment in UK practice, is considered off-label, and requires good patient adherence and clinical follow-up
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