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Navigating GLP-1 Side Effects
Fatigue and energy fluctuations Fatigue is a frequently reported side effect, particularly in the first few weeks of treatment and after dose escalations
Third generation: multi-receptor agonists Tirzepatide targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously, producing greater metabolic effects than GLP-1 alone: Mounjaro , once-weekly injection for type 2 diabetes (FDA-approved 2022)
Central to this complexity is a dysregulated host response, driven by hyperinflammation, immune suppression, and profound mitochondrial and metabolic dysfunction
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15 GongX.WangQ.FuD.TangX.WangY.WangG.et al (2013)
