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Activation of the UPR generally serves as a readout for ER stress, but it is not clear what diminished ER stress implies in terms of an actual accumulation of unfolded proteins, particularly because some stressors, such as palmitate loading, activate the UPR apparently independent of the protein folding process (Volmer et al., 2013)
Mechanisms of action of mycophenolate mofetil
Another class of muscle diseases characterized by mitochondrial dysfunction is IBM, which primarily affects older individuals
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