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364 The affected astrocytes demonstrate profound loss of function, in particular impaired K + buffering, 365,366 compromised H + transport, 367 and substantial decrease in glutamate uptake

10.1016/j.amjms.2025.04.020 88 HendersonR.KimS.LeeE

This review highlights that the dominance of M2-like TAMs in the OC TME creates an environment that supports tumor survival, promotes angiogenesis, facilitates metastasis, and suppresses adaptive immune responses through the secretion of various pro-tumorigenic factors such as IL-10, TGF-, and VEGF

This requirement connects the formulation to clinical judgment rather than general consumer demand

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