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Figure 2 Within the SOC level, gastrointestinal system disorders in overall GLP-1 RAs were overreported compared with the background frequency (ROR 1.46, PRR 1.33, IC 0.41, EBGM 1.33), which were further attributed to liraglutide (ROR 2.39, PRR 1.84, IC 0.88, EBGM 1.33), dulaglutide (ROR 1.39, PRR 1.28, IC 0.36, EBGM 1.25), and semaglutide (ROR 3.00, PRR 2.10, IC 1.07, EBGM 2.10), while exenatide (ROR 0.57, PRR 0.63, IC 0.68, EBGM 0.63) and lixisenatide (ROR 0.51, PRR 0.57, IC 0.81, EBGM 0.57) did not show the association with gastrointestinal AEs ( Table 2 )
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For comparison, the modified GHRH analog CJC-1295 (specifically the version without DAC, which is what is commonly used in modern clinics) has a longer functional duration that keeps the GHRH stimulus present long enough for a more meaningful, sustained growth hormone pulse to occur
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