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The doses tested were 6.25 mg, 12.5 mg, and 25 mg daily
At the same time, history offers numerous examples of treatments that appeared promising early on but later revealed safety concerns, unexpected adverse effects, or limited long-term benefit
Statistically significant improvements in BMI, waist circumference, glycemic control, blood pressure and lipid profile were documented
Beta-arrestin is responsible for receptor internalization, which is essentially the body pulling receptors off the cell surface and reducing their availability
To understand the mechanism in depth, see our overview of the GLP-1 pathway
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