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These compounds target overlapping receptor systems, and combining them dramatically increases the risk of severe gastrointestinal side effects without proportional benefit

Glucagon-like peptide-1 was identified as a potent insulinotropic factor in the 1980s

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The MHRA recommends that healthcare professionals remain vigilant for hypersensitivity reactions when initiating any new medication, and patients should be counselled on recognising the signs of allergic reactions before their first dose

Journal of Neurochemistry 59 , 15311540, doi:10.1111/jnc.1992.59.issue-4 (1992)