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In the gas-fluid organoids derived from colon cancer, the efficacy of 5-FU, irinotecan, and oxaliplatin is enhanced by hedgehog signaling inhibitors through the suppression of GLI-1 expression, thereby reducing drug resistance [234]

It is concluded that earlier trials are of short duration, on small sample sizes and did not document patient satisfaction, duration of depigmenting effect or need for repeat treatments

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