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Plasma half-life is 2-3 hours, but intracellular glutathione levels remain elevated for 18-24 hours after a single subcutaneous dose (Richie et al., European Journal of Nutrition , 2015)

A 2023 observational study published in Obesity (N = 312 on various GLP-1 agonists) found that patients in the lowest quartile of dietary fiber intake lost 2.3 kg less than those in the highest quartile at 6 months, after controlling for drug dose [8]

Most patients report similar weight loss results with compounded semaglutide compared to the brand-name versions, assuming the compounded medication is properly formulated and dosed correctly

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