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For example, a meta-analysis found that two copies of the MTHFR C677T variant (A/A, homozygous) increase the relative risk of heart disease by 38%.[ref][ref] However, not all studies agree, and a large prospective study (n=6,000) found that older people with two copies of the C677T allele were at a 30% decreased risk of death from cardiovascular disease when other parameters were included.[ref] The increased risk is not just due to high homocysteine
Hence, further research needs to take this inter-individual variation into account and is discussed later in this paper ( 3
Pu et al., Highly-entangled hydrogel electrolyte for fast charging/discharging properties in aqueous zinc ion batteries
In practice, the clinical trials for cagrilintide report tolerability outcomes and adverse event patterns alongside efficacy endpoints, because these factors influence dose escalation and continuation within a protocol
doi: 10.1530/eje.0.1360445
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