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406 Nonviral approaches for p53 gene delivery Given the increased attention given to p53 cDNA and mRNA delivery, small interfering RNA (siRNA) oligonucleotides that target specific p53 mutants to reduce GOF and DN effects are also being developed

Glutathione is a naturally occurring antioxidant in the body that helps to neutralize free radicals and protect cells from damage

Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitric oxide synthase and protein kinase C-eta in peripheral blood monocyte-derived macrophages

As the terminal enzyme downstream of COX-2, mPGES-1 can catalyze the biosynthesis of PGE 2 with fewer side effects and, ideally, cannot affect the formation of other housekeeping PGs