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Description

Data presented herein support the notion that prolonged exposure to GLP-1R stimulation can also induce glucose competence by a secondary mechanism involving up-regulation of glycolytic enzymes, and consequently glycolytic flux, arguably the most important stimulus-secretion coupling factor generating pathway in -cells

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Mice with knockin of the L973F-IR showed similar alterations in signaling in vivo, and this led to decreased insulin sensitivity, a modest increase in growth, and decreased weight gain when mice were challenged with a high-fat diet

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The broader Spartan research library covers the GH/IGF axis in more detail across multiple compound entries

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