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The US Food and Drug Administration (FDA) has approved oral and intravenous (IV) L-carnitine for the treatment of primary and secondary carnitine deficiency as a result of inborn errors of metabolism

Additionally, new or worsening constipation accompanied by unexplained weight loss (beyond expected therapeutic weight reduction), persistent changes in stool caliber, or alternating constipation and diarrhea warrants evaluation to exclude structural or neoplastic causes, particularly in patients age 45 or older or those with family history of colorectal cancer

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Composition Molecular profile

Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine