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In Phase 2 trials, the most common side effects were nausea, vomiting, diarrhea, and constipation, consistent with other GLP-1 class drugs

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Deborah Ekstrom

In this review, we systematically examine the molecular and cellular determinants of drug response and resistance across 22 cancer types, highlighting key resistance mechanisms such as compensatory pathway activation, phenotypic plasticity, immune evasion, enhanced DNA damage repair, and the survival of drug-tolerant persister cells