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Biochem Pharmacol 164:3444 Langlois JA, Mussolino ME, Visser M, Looker AC, Harris T, Madans J (2001) Weight loss from maximum body weight among middle-aged and older white women and the risk of hip fracture: the NHANES I epidemiologic follow-up study
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A phase 2 trial of semaglutide 2.4 mg in 71 cirrhotic patients confirmed an acceptable safety profile without significant decompensation events, although the primary histological endpoint was not met, possibly due to the limited ability of antifibrotic remodeling to achieve biopsy-detectable fibrosis stage improvement in established cirrhosis over 48 weeks [46]
Safety: Pycnogenol has been used in many studies for various conditions and has a strong safety record
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