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Fusions with the [G 4 S] 3 A linker to the antibody light chain displayed potent GLP-1R activation (EC 50 : 100300 pM) whilst PCSK9 binding activity decreased by 2-70-fold relative to the parental anti-PCSK9 antibodies
Participants taking semaglutide lost an average of 15.2% of their initial body weight, while those on the placebo only lost 2.6%
Nausea and diarrhoea are very common, and vomiting is common with GLP-1 receptor agonists according to the SmPC, and can lead to significant fluid loss
However, its important to remember that semaglutide is not a cure-all
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