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A responsible practitioner should explain: The expected benefits of a recommendation Possible risks and side effects Reasonable alternatives The quality and limitations of available evidence How progress will be measured When treatment should be changed or stopped When referral to another healthcare professional is appropriate Be cautious of providers who promise cures, discourage needed medical care, recommend extensive testing without a clear purpose, or cannot explain their professional credentials

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This regulated necrotic cell death is activated in response to Fas/FasL signaling, CD59 ligation combined with pore formation, mediated by ROS, ceramide, and advanced glycation end products (AGEs) [28]