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People with active cancer, recent cancer history, or known cancer predispositions are not candidates for the peptide
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The FDA-approved maximum for weight management (through Wegovy) is 2.4mg per week
Although the enrichment of L-cells by pharmacological agents can be a novel approach for improving insulin secretion, glucose tolerance and the treatment of T2DM, more research for the specific differentiation of L-cells and the translation of in vitro and animal data to humans, are needed for the success of this approach
As for W303-1b/gsh1/pro1 or W303-1b/gsh1/proB, the overexpression of introduced Pro1 or ProB under the control of strong constitutive GAP promoter might allow a small amount of GSH in the host strains conferring tolerance to oxidative stress
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