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Abbreviations EX: Exenatide SEM: Semaglutide 5-Aza: 5-Azacytidine AMH: Anti-Mllerian hormone AR: Androgen receptor Ctrl: Control CpG: Cytosine-phosphate-guanine DHT: Dihydrotestosterone DNMT: DNA methyltransferase ELISA: Enzyme-linked immunosorbent assay Fer-1: Ferrostatin-1 GSH: Reduced glutathione GSSG: Oxidized glutathione GPX4: Glutathione peroxidase 4 H&E: Hematoxylin and eosin IF: Immunofluorescence IHC: Immunohistochemistry IR: Insulin resistance LCMS/MS: Liquid chromatographytandem mass spectrometry MDA: Malondialdehyde MSP: Methylation-specific polymerase chain reaction BSP: Bisulfite sequencing polymerase chain reaction PCOS: Polycystic ovary syndrome ROS: Reactive oxygen species References Carmina E, Longo RA (2023) Semaglutide treatment of excessive body weight in obese PCOS patients unresponsive to lifestyle programs
Probiotics with Lactobacillus and Bifidobacterium strains may help restore healthy gut bacteria, though evidence is mixed
Synergistic Release: Quantitative analysis of growth hormone secretion pulses when GHRP-2 is co-administered with GHRH analogues
Apart from the TCM botanical drug metabolites previously discussed, additional metabolites from TCM botanical drugs have demonstrated efficacy in ameliorating PCOS-IR (Table 1)
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